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UmbracoSurgery »  Research »  Liang You, Ph.D. »  Developing Novel Therapeutics for Treatment of Mesothelioma and Lung Cancer Metastasis

Developing Novel Therapeutics for Treatment of Mesothelioma and Lung Cancer Metastasis

Liang You And The goal of this project is to test potential therapeutics for mesothelioma in our newly developed Cullin 4A (Cul4A)-midiated metastasis model in which mouse mesothelioma cells are directly injected into the pleural cavity of immune-competent mice and to better understand the role of Hippo/YAP signaling pathways in Cul4A-mediated mouse mesothelioma metastasis. This builds on past work in collaboration with Dr. Jian-Hua Mao, Dr. Zhidong Xu, Dr. Yi-Lin Yang, and Dr.  David Jablons that investigated the role of Cul4A in genomic instability and tumor development. 

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